I can think of a couple of insects that would fit that category, but you specifically said animal, and the first thing that came to my mind was the African antelope the Waterbuck (Kobus ellipsiprymnus)
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These antelope actually don’t live in the water but do flee to water when they are chased by predators. According to the program I watched (I believe it was on BBC) the males secrete a substance on their skin that makes them taste bad. I think this is a hypothesis and has not been proven. Anyway, that was the first animal that came to mind when I saw your question.
Source: Donald Behnke